Research Articles
Evaluating Biomarker Specificity for Target Foods: A Comprehensive Framework for Validation and Application
This article provides a systematic framework for researchers and drug development professionals to evaluate the specificity of biomarkers for target foods.
Biomarker Robustness in Habitual Diet Contexts: Validation, Challenges, and Applications in Biomedical Research
This article provides a comprehensive analysis of the robustness of dietary biomarkers within habitual diet contexts, addressing a critical need for objective dietary assessment in biomedical research.
Matrices in Focus: A 2025 Guide to Comparative Performance in Biomarker Analysis for Drug Development
This article provides a comprehensive comparative analysis of different biomarker matrices—including blood, urine, tissue, and emerging liquid biopsy sources—for researchers and drug development professionals.
Navigating the Complex Landscape of Biomarker Validation Across Diverse Study Populations
This article provides a comprehensive roadmap for researchers and drug development professionals on validating biomarkers across diverse populations.
Recovery vs. Concentration Biomarkers: A Comparative Analysis for Objective Measurement in Drug Development and Clinical Research
This article provides a comprehensive comparison of recovery and concentration biomarkers, two fundamental classes for objective measurement in biomedical research.
Dose-Response Relationships in Dietary Biomarkers: From Discovery to Clinical Validation
This article provides a comprehensive resource for researchers and drug development professionals on the assessment of dose-response relationships for dietary biomarkers.
Time-Response Kinetics of Food Intake Biomarkers: From Discovery to Clinical Application
This comprehensive review explores the critical role of time-response kinetics in the development and validation of dietary biomarkers for research and clinical applications.
Correcting for Covariate-Dependent Measurement Error: A Practical Guide for Biomedical Researchers
Covariate-dependent measurement error, where the error in a mismeasured variable systematically varies with another covariate, is a pervasive yet often unaddressed problem that can severely bias estimates in biomedical research,...
Controlling for Non-Food Determinants of Biomarker Levels: A Strategic Framework for Researchers and Drug Developers
This article provides a comprehensive framework for researchers and drug development professionals to identify, understand, and control for the critical non-food factors that confound biomarker levels.
Optimizing Controlled Feeding Study Designs for Robust Dietary Biomarker Development
This article provides a comprehensive guide for researchers and drug development professionals on designing and executing controlled feeding studies to discover and validate novel dietary biomarkers.